Characterization and cloning of long neurotoxin homolog from Naja naja atra
نویسندگان
چکیده
منابع مشابه
Structural-functional studies of peptides derived from a long-chain snake neurotoxin Naja naja oxiana
Introduction: The design and structural characterization of mini-proteins with a compact, folded structure provide insight into the complex architecture of proteins today and has long been a challenging issue in structural- functional studies. Alpha neurotoxins from snake venom have a distinct folded structure comprised of a disulphide core and three loops or “fingers” each of these loops are c...
متن کاملAnti-inflammatory effects of Neurotoxin-Nna, a peptide separated from the venom of Naja naja atra
BACKGROUND Neurotoxin-Nna (NT), an analgesic peptide separated from the venom of Naja naja atra, has reported to have an exceptional specificity to block transmission of the nerve impulse by binding to the α- subunit of the nicotinic acetylcholine receptor in the membrane. However, little information is available on the anti-inflammatory effects of NT. Therefore, the anti-inflammatory activity ...
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The unfolding kinetics of cardiotoxin analogue VI from Taiwan cobra (Naja naja atra) have been studied at 473 K, pH 7.0 in the presence of 0.1 M NaCl using molecular dynamics simulations for 50 ns. Trajectory structures stored at every 25 ps (2000 structures) were probed at molecular (RMSD and radius of gyration) and residue (RMSF, surface area accessibility and secondary structures) level reso...
متن کاملProteomic characterization of two snake venoms: Naja naja atra and Agkistrodon halys.
Snake venom is a complex mixture of proteins and peptides, and a number of studies have described the biological properties of several venomous proteins. Nevertheless, a complete proteomic profile of venom from any of the many species of snake is not available. Proteomics now makes it possible to globally identify proteins from a complex mixture. To assess the venom proteomic profiles from Naja...
متن کاملDifferential Effects of Naja naja atra Venom on Immune Activity
Previous studies reported that Naja naja atra venom (NNAV) inhibited inflammation and adjuvant arthritis. Here we investigated the role of NNAV in regulation of immune responses in mice. Oral administration of NNAV to normal mice showed significant increase in natural killer cell activity, B lymphocyte proliferation stimulated by lipopolysaccharides, and antibody production in response to sheep...
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ژورنال
عنوان ژورنال: IUBMB Life
سال: 1998
ISSN: 1521-6543
DOI: 10.1080/15216549800204772